Vitamin B12b Enhances the Cytotoxicity of Diethyldithiocarbamate in a Synergistic Manner, Inducing the Paraptosis-Like Death of Human Larynx Carcinoma Cells
Identifieur interne : 000011 ( an2020/Analysis ); précédent : 000010; suivant : 000012Vitamin B12b Enhances the Cytotoxicity of Diethyldithiocarbamate in a Synergistic Manner, Inducing the Paraptosis-Like Death of Human Larynx Carcinoma Cells
Auteurs : Marina Solovieva ; Yuri Shatalin ; Roman Fadeev ; Olga Krestinina ; Yulia Baburina ; Alexey Kruglov ; Ekaterina Kharechkina ; Margarita Kobyakova ; Vadim Rogachevsky ; Elena Shishkova ; Vladimir AkatovSource :
- Biomolecules [ 2218-273X ] ; 2020.
Abstract
We have shown that hydroxycobalamin (vitamin B12b) increases the toxicity of diethyldithiocarbamate (DDC) to tumor cells by catalyzing the formation of disulfiram (DSF) oxi-derivatives. The purpose of this study was to elucidate the mechanism of tumor cell death induced by the combination DDC + B12b. It was found that cell death induced by DDC + B12b differed from apoptosis, autophagy, and necrosis. During the initiation of cell death, numerous vacuoles formed from ER cisterns in the cytoplasm, and cell death was partially suppressed by the inhibitors of protein synthesis and folding, the IP3 receptor inhibitor as well as by thiols. At this time, a short-term rise in the expression of ER-stress markers BiP and PERK with a steady increase in the expression of CHOP were detected. After the vacuolization of the cytoplasm, functional disorders of mitochondria and an increase in the generation of superoxide anion in them occurred. Taken together, the results obtained indicate that DDC and B12b used in combination exert a synergistic toxic effect on tumor cells by causing severe ER stress, extensive ER vacuolization, and inhibition of apoptosis, which ultimately leads to the induction of paraptosis-like cell death.
Url:
DOI: 10.3390/biom10010069
PubMed: 31906414
PubMed Central: 7023477
Affiliations:
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Vitamin B<sub>12b</sub> Enhances the Cytotoxicity of Diethyldithiocarbamate in a Synergistic Manner, Inducing the Paraptosis-Like Death of Human Larynx Carcinoma Cells</title><author><name sortKey="Solovieva, Marina" sort="Solovieva, Marina" uniqKey="Solovieva M" first="Marina" last="Solovieva">Marina Solovieva</name><affiliation><nlm:aff id="af1-biomolecules-10-00069">Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino, 142290 Moscow Region, Russia;<email>m_solovieva@iteb.ru</email> (M.S.);<email>yury.shatalin@yandex.ru</email> (Y.S.);<email>fadeevrs@gmail.com</email> (R.F.);<email>ovkres@mail.ru</email> (O.K.);<email>byul@rambler.ru</email> (Y.B.);<email>krugalex@rambler.ru</email> (A.K.);<email>katya.kypri@gmail.com</email> (E.K.);<email>ritaaaaa49@gmail.com</email> (M.K.)</nlm:aff></affiliation></author><author><name sortKey="Shatalin, Yuri" sort="Shatalin, Yuri" uniqKey="Shatalin Y" first="Yuri" last="Shatalin">Yuri Shatalin</name><affiliation><nlm:aff id="af1-biomolecules-10-00069">Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino, 142290 Moscow Region, Russia;<email>m_solovieva@iteb.ru</email> (M.S.);<email>yury.shatalin@yandex.ru</email> (Y.S.);<email>fadeevrs@gmail.com</email> (R.F.);<email>ovkres@mail.ru</email> (O.K.);<email>byul@rambler.ru</email> (Y.B.);<email>krugalex@rambler.ru</email> (A.K.);<email>katya.kypri@gmail.com</email> (E.K.);<email>ritaaaaa49@gmail.com</email> (M.K.)</nlm:aff></affiliation></author><author><name sortKey="Fadeev, Roman" sort="Fadeev, Roman" uniqKey="Fadeev R" first="Roman" last="Fadeev">Roman Fadeev</name><affiliation><nlm:aff id="af1-biomolecules-10-00069">Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino, 142290 Moscow Region, Russia;<email>m_solovieva@iteb.ru</email> (M.S.);<email>yury.shatalin@yandex.ru</email> (Y.S.);<email>fadeevrs@gmail.com</email> (R.F.);<email>ovkres@mail.ru</email> (O.K.);<email>byul@rambler.ru</email> (Y.B.);<email>krugalex@rambler.ru</email> (A.K.);<email>katya.kypri@gmail.com</email> (E.K.);<email>ritaaaaa49@gmail.com</email> (M.K.)</nlm:aff></affiliation></author><author><name sortKey="Krestinina, Olga" sort="Krestinina, Olga" uniqKey="Krestinina O" first="Olga" last="Krestinina">Olga Krestinina</name><affiliation><nlm:aff id="af1-biomolecules-10-00069">Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino, 142290 Moscow Region, Russia;<email>m_solovieva@iteb.ru</email> (M.S.);<email>yury.shatalin@yandex.ru</email> (Y.S.);<email>fadeevrs@gmail.com</email> (R.F.);<email>ovkres@mail.ru</email> (O.K.);<email>byul@rambler.ru</email> (Y.B.);<email>krugalex@rambler.ru</email> (A.K.);<email>katya.kypri@gmail.com</email> (E.K.);<email>ritaaaaa49@gmail.com</email> (M.K.)</nlm:aff></affiliation></author><author><name sortKey="Baburina, Yulia" sort="Baburina, Yulia" uniqKey="Baburina Y" first="Yulia" last="Baburina">Yulia Baburina</name><affiliation><nlm:aff id="af1-biomolecules-10-00069">Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino, 142290 Moscow Region, Russia;<email>m_solovieva@iteb.ru</email> (M.S.);<email>yury.shatalin@yandex.ru</email> (Y.S.);<email>fadeevrs@gmail.com</email> (R.F.);<email>ovkres@mail.ru</email> (O.K.);<email>byul@rambler.ru</email> (Y.B.);<email>krugalex@rambler.ru</email> (A.K.);<email>katya.kypri@gmail.com</email> (E.K.);<email>ritaaaaa49@gmail.com</email> (M.K.)</nlm:aff></affiliation></author><author><name sortKey="Kruglov, Alexey" sort="Kruglov, Alexey" uniqKey="Kruglov A" first="Alexey" last="Kruglov">Alexey Kruglov</name><affiliation><nlm:aff id="af1-biomolecules-10-00069">Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino, 142290 Moscow Region, Russia;<email>m_solovieva@iteb.ru</email> (M.S.);<email>yury.shatalin@yandex.ru</email> (Y.S.);<email>fadeevrs@gmail.com</email> (R.F.);<email>ovkres@mail.ru</email> (O.K.);<email>byul@rambler.ru</email> (Y.B.);<email>krugalex@rambler.ru</email> (A.K.);<email>katya.kypri@gmail.com</email> (E.K.);<email>ritaaaaa49@gmail.com</email> (M.K.)</nlm:aff></affiliation></author><author><name sortKey="Kharechkina, Ekaterina" sort="Kharechkina, Ekaterina" uniqKey="Kharechkina E" first="Ekaterina" last="Kharechkina">Ekaterina Kharechkina</name><affiliation><nlm:aff id="af1-biomolecules-10-00069">Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino, 142290 Moscow Region, Russia;<email>m_solovieva@iteb.ru</email> (M.S.);<email>yury.shatalin@yandex.ru</email> (Y.S.);<email>fadeevrs@gmail.com</email> (R.F.);<email>ovkres@mail.ru</email> (O.K.);<email>byul@rambler.ru</email> (Y.B.);<email>krugalex@rambler.ru</email> (A.K.);<email>katya.kypri@gmail.com</email> (E.K.);<email>ritaaaaa49@gmail.com</email> (M.K.)</nlm:aff></affiliation></author><author><name sortKey="Kobyakova, Margarita" sort="Kobyakova, Margarita" uniqKey="Kobyakova M" first="Margarita" last="Kobyakova">Margarita Kobyakova</name><affiliation><nlm:aff id="af1-biomolecules-10-00069">Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino, 142290 Moscow Region, Russia;<email>m_solovieva@iteb.ru</email> (M.S.);<email>yury.shatalin@yandex.ru</email> (Y.S.);<email>fadeevrs@gmail.com</email> (R.F.);<email>ovkres@mail.ru</email> (O.K.);<email>byul@rambler.ru</email> (Y.B.);<email>krugalex@rambler.ru</email> (A.K.);<email>katya.kypri@gmail.com</email> (E.K.);<email>ritaaaaa49@gmail.com</email> (M.K.)</nlm:aff></affiliation></author><author><name sortKey="Rogachevsky, Vadim" sort="Rogachevsky, Vadim" uniqKey="Rogachevsky V" first="Vadim" last="Rogachevsky">Vadim Rogachevsky</name><affiliation><nlm:aff id="af2-biomolecules-10-00069">Institute of Cell Biophysics, Russian Academy of Sciences, Pushchino, 142290 Moscow Region, Russia;<email>vadim_rogachevsky@synapsis.ru</email> (V.R.);<email>shishkova@neuro.nnov.ru</email> (E.S.)</nlm:aff></affiliation></author><author><name sortKey="Shishkova, Elena" sort="Shishkova, Elena" uniqKey="Shishkova E" first="Elena" last="Shishkova">Elena Shishkova</name><affiliation><nlm:aff id="af2-biomolecules-10-00069">Institute of Cell Biophysics, Russian Academy of Sciences, Pushchino, 142290 Moscow Region, Russia;<email>vadim_rogachevsky@synapsis.ru</email> (V.R.);<email>shishkova@neuro.nnov.ru</email> (E.S.)</nlm:aff></affiliation></author><author><name sortKey="Akatov, Vladimir" sort="Akatov, Vladimir" uniqKey="Akatov V" first="Vladimir" last="Akatov">Vladimir Akatov</name><affiliation><nlm:aff id="af1-biomolecules-10-00069">Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino, 142290 Moscow Region, Russia;<email>m_solovieva@iteb.ru</email> (M.S.);<email>yury.shatalin@yandex.ru</email> (Y.S.);<email>fadeevrs@gmail.com</email> (R.F.);<email>ovkres@mail.ru</email> (O.K.);<email>byul@rambler.ru</email> (Y.B.);<email>krugalex@rambler.ru</email> (A.K.);<email>katya.kypri@gmail.com</email> (E.K.);<email>ritaaaaa49@gmail.com</email> (M.K.)</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">31906414</idno><idno type="pmc">7023477</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7023477</idno><idno type="RBID">PMC:7023477</idno><idno type="doi">10.3390/biom10010069</idno><date when="2020">2020</date><idno type="wicri:Area/Pmc/Corpus">000431</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000431</idno><idno type="wicri:Area/Pmc/Curation">000431</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000431</idno><idno type="wicri:Area/Pmc/Checkpoint">000006</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000006</idno><idno type="wicri:Area/Ncbi/Merge">000E04</idno><idno type="wicri:Area/Ncbi/Curation">000E04</idno><idno type="wicri:Area/Ncbi/Checkpoint">000E04</idno><idno type="wicri:Area/Main/Merge">000011</idno><idno type="wicri:Area/Main/Curation">000011</idno><idno type="wicri:Area/Main/Exploration">000011</idno><idno type="wicri:Area/an2020/Extraction">000011</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Vitamin B<sub>12b</sub> Enhances the Cytotoxicity of Diethyldithiocarbamate in a Synergistic Manner, Inducing the Paraptosis-Like Death of Human Larynx Carcinoma Cells</title><author><name sortKey="Solovieva, Marina" sort="Solovieva, Marina" uniqKey="Solovieva M" first="Marina" last="Solovieva">Marina Solovieva</name><affiliation><nlm:aff id="af1-biomolecules-10-00069">Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino, 142290 Moscow Region, Russia;<email>m_solovieva@iteb.ru</email> (M.S.);<email>yury.shatalin@yandex.ru</email> (Y.S.);<email>fadeevrs@gmail.com</email> (R.F.);<email>ovkres@mail.ru</email> (O.K.);<email>byul@rambler.ru</email> (Y.B.);<email>krugalex@rambler.ru</email> (A.K.);<email>katya.kypri@gmail.com</email> (E.K.);<email>ritaaaaa49@gmail.com</email> (M.K.)</nlm:aff></affiliation></author><author><name sortKey="Shatalin, Yuri" sort="Shatalin, Yuri" uniqKey="Shatalin Y" first="Yuri" last="Shatalin">Yuri Shatalin</name><affiliation><nlm:aff id="af1-biomolecules-10-00069">Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino, 142290 Moscow Region, Russia;<email>m_solovieva@iteb.ru</email> (M.S.);<email>yury.shatalin@yandex.ru</email> (Y.S.);<email>fadeevrs@gmail.com</email> (R.F.);<email>ovkres@mail.ru</email> (O.K.);<email>byul@rambler.ru</email> (Y.B.);<email>krugalex@rambler.ru</email> (A.K.);<email>katya.kypri@gmail.com</email> (E.K.);<email>ritaaaaa49@gmail.com</email> (M.K.)</nlm:aff></affiliation></author><author><name sortKey="Fadeev, Roman" sort="Fadeev, Roman" uniqKey="Fadeev R" first="Roman" last="Fadeev">Roman Fadeev</name><affiliation><nlm:aff id="af1-biomolecules-10-00069">Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino, 142290 Moscow Region, Russia;<email>m_solovieva@iteb.ru</email> (M.S.);<email>yury.shatalin@yandex.ru</email> (Y.S.);<email>fadeevrs@gmail.com</email> (R.F.);<email>ovkres@mail.ru</email> (O.K.);<email>byul@rambler.ru</email> (Y.B.);<email>krugalex@rambler.ru</email> (A.K.);<email>katya.kypri@gmail.com</email> (E.K.);<email>ritaaaaa49@gmail.com</email> (M.K.)</nlm:aff></affiliation></author><author><name sortKey="Krestinina, Olga" sort="Krestinina, Olga" uniqKey="Krestinina O" first="Olga" last="Krestinina">Olga Krestinina</name><affiliation><nlm:aff id="af1-biomolecules-10-00069">Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino, 142290 Moscow Region, Russia;<email>m_solovieva@iteb.ru</email> (M.S.);<email>yury.shatalin@yandex.ru</email> (Y.S.);<email>fadeevrs@gmail.com</email> (R.F.);<email>ovkres@mail.ru</email> (O.K.);<email>byul@rambler.ru</email> (Y.B.);<email>krugalex@rambler.ru</email> (A.K.);<email>katya.kypri@gmail.com</email> (E.K.);<email>ritaaaaa49@gmail.com</email> (M.K.)</nlm:aff></affiliation></author><author><name sortKey="Baburina, Yulia" sort="Baburina, Yulia" uniqKey="Baburina Y" first="Yulia" last="Baburina">Yulia Baburina</name><affiliation><nlm:aff id="af1-biomolecules-10-00069">Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino, 142290 Moscow Region, Russia;<email>m_solovieva@iteb.ru</email> (M.S.);<email>yury.shatalin@yandex.ru</email> (Y.S.);<email>fadeevrs@gmail.com</email> (R.F.);<email>ovkres@mail.ru</email> (O.K.);<email>byul@rambler.ru</email> (Y.B.);<email>krugalex@rambler.ru</email> (A.K.);<email>katya.kypri@gmail.com</email> (E.K.);<email>ritaaaaa49@gmail.com</email> (M.K.)</nlm:aff></affiliation></author><author><name sortKey="Kruglov, Alexey" sort="Kruglov, Alexey" uniqKey="Kruglov A" first="Alexey" last="Kruglov">Alexey Kruglov</name><affiliation><nlm:aff id="af1-biomolecules-10-00069">Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino, 142290 Moscow Region, Russia;<email>m_solovieva@iteb.ru</email> (M.S.);<email>yury.shatalin@yandex.ru</email> (Y.S.);<email>fadeevrs@gmail.com</email> (R.F.);<email>ovkres@mail.ru</email> (O.K.);<email>byul@rambler.ru</email> (Y.B.);<email>krugalex@rambler.ru</email> (A.K.);<email>katya.kypri@gmail.com</email> (E.K.);<email>ritaaaaa49@gmail.com</email> (M.K.)</nlm:aff></affiliation></author><author><name sortKey="Kharechkina, Ekaterina" sort="Kharechkina, Ekaterina" uniqKey="Kharechkina E" first="Ekaterina" last="Kharechkina">Ekaterina Kharechkina</name><affiliation><nlm:aff id="af1-biomolecules-10-00069">Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino, 142290 Moscow Region, Russia;<email>m_solovieva@iteb.ru</email> (M.S.);<email>yury.shatalin@yandex.ru</email> (Y.S.);<email>fadeevrs@gmail.com</email> (R.F.);<email>ovkres@mail.ru</email> (O.K.);<email>byul@rambler.ru</email> (Y.B.);<email>krugalex@rambler.ru</email> (A.K.);<email>katya.kypri@gmail.com</email> (E.K.);<email>ritaaaaa49@gmail.com</email> (M.K.)</nlm:aff></affiliation></author><author><name sortKey="Kobyakova, Margarita" sort="Kobyakova, Margarita" uniqKey="Kobyakova M" first="Margarita" last="Kobyakova">Margarita Kobyakova</name><affiliation><nlm:aff id="af1-biomolecules-10-00069">Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino, 142290 Moscow Region, Russia;<email>m_solovieva@iteb.ru</email> (M.S.);<email>yury.shatalin@yandex.ru</email> (Y.S.);<email>fadeevrs@gmail.com</email> (R.F.);<email>ovkres@mail.ru</email> (O.K.);<email>byul@rambler.ru</email> (Y.B.);<email>krugalex@rambler.ru</email> (A.K.);<email>katya.kypri@gmail.com</email> (E.K.);<email>ritaaaaa49@gmail.com</email> (M.K.)</nlm:aff></affiliation></author><author><name sortKey="Rogachevsky, Vadim" sort="Rogachevsky, Vadim" uniqKey="Rogachevsky V" first="Vadim" last="Rogachevsky">Vadim Rogachevsky</name><affiliation><nlm:aff id="af2-biomolecules-10-00069">Institute of Cell Biophysics, Russian Academy of Sciences, Pushchino, 142290 Moscow Region, Russia;<email>vadim_rogachevsky@synapsis.ru</email> (V.R.);<email>shishkova@neuro.nnov.ru</email> (E.S.)</nlm:aff></affiliation></author><author><name sortKey="Shishkova, Elena" sort="Shishkova, Elena" uniqKey="Shishkova E" first="Elena" last="Shishkova">Elena Shishkova</name><affiliation><nlm:aff id="af2-biomolecules-10-00069">Institute of Cell Biophysics, Russian Academy of Sciences, Pushchino, 142290 Moscow Region, Russia;<email>vadim_rogachevsky@synapsis.ru</email> (V.R.);<email>shishkova@neuro.nnov.ru</email> (E.S.)</nlm:aff></affiliation></author><author><name sortKey="Akatov, Vladimir" sort="Akatov, Vladimir" uniqKey="Akatov V" first="Vladimir" last="Akatov">Vladimir Akatov</name><affiliation><nlm:aff id="af1-biomolecules-10-00069">Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino, 142290 Moscow Region, Russia;<email>m_solovieva@iteb.ru</email> (M.S.);<email>yury.shatalin@yandex.ru</email> (Y.S.);<email>fadeevrs@gmail.com</email> (R.F.);<email>ovkres@mail.ru</email> (O.K.);<email>byul@rambler.ru</email> (Y.B.);<email>krugalex@rambler.ru</email> (A.K.);<email>katya.kypri@gmail.com</email> (E.K.);<email>ritaaaaa49@gmail.com</email> (M.K.)</nlm:aff></affiliation></author></analytic><series><title level="j">Biomolecules</title><idno type="eISSN">2218-273X</idno><imprint><date when="2020">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>We have shown that hydroxycobalamin (vitamin B<sub>12b</sub>) increases the toxicity of diethyldithiocarbamate (DDC) to tumor cells by catalyzing the formation of disulfiram (DSF) oxi-derivatives. The purpose of this study was to elucidate the mechanism of tumor cell death induced by the combination DDC + B<sub>12b</sub>. It was found that cell death induced by DDC + B<sub>12b</sub> differed from apoptosis, autophagy, and necrosis. During the initiation of cell death, numerous vacuoles formed from ER cisterns in the cytoplasm, and cell death was partially suppressed by the inhibitors of protein synthesis and folding, the IP3 receptor inhibitor as well as by thiols. At this time, a short-term rise in the expression of ER-stress markers BiP and PERK with a steady increase in the expression of CHOP were detected. After the vacuolization of the cytoplasm, functional disorders of mitochondria and an increase in the generation of superoxide anion in them occurred. Taken together, the results obtained indicate that DDC and B<sub>12b</sub> used in combination exert a synergistic toxic effect on tumor cells by causing severe ER stress, extensive ER vacuolization, and inhibition of apoptosis, which ultimately leads to the induction of paraptosis-like cell death.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Hendren, R L" uniqKey="Hendren R">R.L. Hendren</name></author><author><name sortKey="James, S J" uniqKey="James S">S.J. James</name></author><author><name sortKey="Widjaja, F" uniqKey="Widjaja F">F. Widjaja</name></author><author><name sortKey="Lawton, B" uniqKey="Lawton B">B. Lawton</name></author><author><name sortKey="Rosenblatt, A" uniqKey="Rosenblatt A">A. Rosenblatt</name></author><author><name sortKey="Bent, S" uniqKey="Bent S">S. Bent</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Thompson, J P" uniqKey="Thompson J">J.P. 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Flaherty</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list></list><tree><noCountry><name sortKey="Akatov, Vladimir" sort="Akatov, Vladimir" uniqKey="Akatov V" first="Vladimir" last="Akatov">Vladimir Akatov</name><name sortKey="Baburina, Yulia" sort="Baburina, Yulia" uniqKey="Baburina Y" first="Yulia" last="Baburina">Yulia Baburina</name><name sortKey="Fadeev, Roman" sort="Fadeev, Roman" uniqKey="Fadeev R" first="Roman" last="Fadeev">Roman Fadeev</name><name sortKey="Kharechkina, Ekaterina" sort="Kharechkina, Ekaterina" uniqKey="Kharechkina E" first="Ekaterina" last="Kharechkina">Ekaterina Kharechkina</name><name sortKey="Kobyakova, Margarita" sort="Kobyakova, Margarita" uniqKey="Kobyakova M" first="Margarita" last="Kobyakova">Margarita Kobyakova</name><name sortKey="Krestinina, Olga" sort="Krestinina, Olga" uniqKey="Krestinina O" first="Olga" last="Krestinina">Olga Krestinina</name><name sortKey="Kruglov, Alexey" sort="Kruglov, Alexey" uniqKey="Kruglov A" first="Alexey" last="Kruglov">Alexey Kruglov</name><name sortKey="Rogachevsky, Vadim" sort="Rogachevsky, Vadim" uniqKey="Rogachevsky V" first="Vadim" last="Rogachevsky">Vadim Rogachevsky</name><name sortKey="Shatalin, Yuri" sort="Shatalin, Yuri" uniqKey="Shatalin Y" first="Yuri" last="Shatalin">Yuri Shatalin</name><name sortKey="Shishkova, Elena" sort="Shishkova, Elena" uniqKey="Shishkova E" first="Elena" last="Shishkova">Elena Shishkova</name><name sortKey="Solovieva, Marina" sort="Solovieva, Marina" uniqKey="Solovieva M" first="Marina" last="Solovieva">Marina Solovieva</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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